P-ISSN 2587-2400 | E-ISSN 2587-196X
Eurasian Journal of Medicine and Oncology Successful Treatment of Rhinocerebral Mucormycosis with Combination of Liposomal Amphotericin B and Caspofungin (LAmB-C): An Anecdotal Clinical Experience that Deserves Further Investigations [EJMO]
EJMO. 2017; 1(3): 172-174 | DOI: 10.14744/ejmo.2017.84803

Successful Treatment of Rhinocerebral Mucormycosis with Combination of Liposomal Amphotericin B and Caspofungin (LAmB-C): An Anecdotal Clinical Experience that Deserves Further Investigations

Hakan Kocoglu1, Yildiz Okuturlar1, Zahide Mine Yazici2, Mehmet Hursitoglu1, Ozlem Harmankaya1, Bahar Pehlivan1, Abdulbaki Kumbasar1
1Department of Internal Medicine, Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey
2Department of Otorhinolaryngology, Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey

Despite surgical interventions and antifungal therapies, the overall mortality of rhino-cerebral mucormycosis remains high. New therapeutic approaches are required in this field. Herein, we presented the first case report of a diabetic patient with rhinocerebral mucormycosis who was successfully treated with surgical intervention and a combination of liposomal amphotericin B (LAmB) (5mg/kg/day) and caspofungin (70mg followed by 50mg daily). We reported an anecdotal clinical experience of successful outcome in established mucormycosis likely to be attributable to the combination of LAmB and caspofungin. The combination of LAmB plus Caspofungin is presumably the best optimal combination therapy for rhino-orbital-cerebral mucormycosis. The potential role of caspofungin in the combination therapy against mucormycosis deserves further investigations.

Keywords: Caspofungin, echinocandins, liposomal amphotericin B, mucormycosis

Hakan Kocoglu, Yildiz Okuturlar, Zahide Mine Yazici, Mehmet Hursitoglu, Ozlem Harmankaya, Bahar Pehlivan, Abdulbaki Kumbasar. Successful Treatment of Rhinocerebral Mucormycosis with Combination of Liposomal Amphotericin B and Caspofungin (LAmB-C): An Anecdotal Clinical Experience that Deserves Further Investigations. EJMO. 2017; 1(3): 172-174

Corresponding Author: Hakan Kocoglu, Türkiye

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