Renal cell carcinoma (RCC) and malignant melanoma (MM) are ranked as the eighth and the fifth most frequent malignancies in the United States, respectively, and the incidence is increasing. Recent studies have shown an increased risk of second primary cancer in patients with RCC or MM, demonstrating a severe risk of RCC in patients with MM, and a severe risk of MM in patients with RCC. Ocular melanoma is a rare melanoma subtype and accounts for 3.7% of all melanoma cases. A potential symmetrical relationship between ocular MM and the development of kidney cancer may be explained by the common risk factors and mechanisms of these 2 malignancies. Chromosome-3 abnormalities have commonly been reported in patients with ocular melanoma and kidney cancers. While previous studies have shown an increased incidence of MM in patients with RCC and vice versa, subanalysis of demographic tumor factors has been unavailable due to the small number of patients who have developed both cancers.
Corresponding Author: Aydin Aytekin