The Effect of Neutrophile Lymphocyte Ratio (NLR) on Disease Free Survival (DFS) and Overall Survival (OS) In Gastric Cancer and its Relation with Clinicopathological Features
Mehmet Akif Ustuner1, Bulent Aksel2, Niyazi Karaman2, Lutfi Dogan21Deparmant of Gastroenterolojic Surgery, Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey, 2Deparmant of General Surgery, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey,
Objectives: Neutrophile-lymphocyte ratio (NLR) is an inflammatory marker and has prognostic significance for many cancers.In this study, we evaluated the prognostic value of NLR ratio and its relation with clinicopathological features in gastric cancer. Methods: A retrospective review of 110 patients who underwent stomach cancer surgery between 2012 and 2014 was performed electronically. Results: The mean age was 63.7±11.6 years.Seventy percent of the patients were male and 43% underwent total and 57% subtotal gastrectomies. According to TNM staging; 11% were in stage 1, 29% in stage 2 and 60% in stage 3. Metastatic/ total lymph node ratio is below 0.3 in 59% of patients. Neutrophil/lymphocyte ratio was found to be greater than 2.5 in 50% of patients and greater than 3 in 33% of patients. The mean NLR value was 3.38±2.7 (1.09-19.1). Conclusion: In our study, while NLR was not detected as an effective factor on disease-free survival; stage, metastatic lymph node ratio, tumor size and localization were found as independent factors effective on overall survival. As a significant factor in multivariate analysis, NLR reflects the immune status of the organism, not the tumor aggressiveness or stage and it is an independent prognostic factor. Keywords: Disease free survival (DFS), gastric cancer, neutrophile lymphocyte ratio (NLR), overall survival (OS)
Cite This Article
Ustuner M, Aksel B, Karaman N, Dogan L. The Effect of Neutrophile Lymphocyte Ratio (NLR) on Disease Free Survival (DFS) and Overall Survival (OS) In Gastric Cancer and its Relation with Clinicopathological Features. EJMO. 2019; 3(3): 186-190
Corresponding Author: Mehmet Akif Ustuner