P-ISSN 2587-2400 | E-ISSN 2587-196X
EJMO Volume : 4 Issue : 4 Year : 2020
EJMO. 2020; 4(4): 292-298 | DOI: 10.14744/ejmo.2020.17777

Expression of Myeloid Cell Leukemia-1 (Mcl-1) Predicts the Survival of Patients with Metastatic Gastric Cancer

Esma Turkmen Bekmez1, Gulsah Safak Orkan2
1Department of Medical Oncology, University of Health Sciences, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey, 2Department of Patology, University of Health Sciences, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey

Objectives: The aim of this study is to investigate the effect of myeloid cell leukemia-1 expression on overall survival in patients with metastatic gastric cancer. Methods: The files of 57 metastatic gastric cancer patients followed in our clinic were reviewed retrospectively. The Mcl-1 expression in tumor tissue was examined immunohistochemically. The Mcl-1 staining level was given in percentage (range: 0-100%). Correlations between the clinicopathological features , progression-free survival, overall survival and Mcl-1 were analyzed. Results: Of the 57 patients in our study, 41 were male and 16 were female. The median age was 66 years. The median Mcl-1 expression value was 70. The median progression-free survival was 7.6 months, median overall survival was 9.3 months. In the multivariate analysis, Mcl-1 expression ?70 and responsiveness to first-line therapy were found to be independent good prognostic factors for overall survival, respectively [17 vs 6 months (p<0.001); 16.3 vs 8.7 months (p=0.04)]. The Mcl-1 expression was higher in pure adenocarcinoma, well-differentiated carcinoma, and visceral organ metastasis (p=0.005, p=0.01, p=0.006, respectively). No relationship was found between Mcl-1 value and gender, age, smoking, performance score, Her-2/neu expression, tumor localization and omental involvement status. Conclusion: In our study, we found that the myeloid cell leukemia-1 expression and responsiveness to first-line therapy are good prognostic factors for overall survival in patients with metastatic gastric


Cite This Article

Turkmen Bekmez E, Safak Orkan G. Expression of Myeloid Cell Leukemia-1 (Mcl-1) Predicts the Survival of Patients with Metastatic Gastric Cancer. EJMO. 2020; 4(4): 292-298

Corresponding Author: Esma Turkmen Bekmez

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