Ahead of Print | DOI: 10.14744/ejmo.2020.41452

Calcified Coronary Lesions in Diabetes – Culmination of Dyslipidaemia and Inflammation

Paras Yadav¹, Sridhar Mangalesh¹, Sharmila Dudani^1
1Army College of Medical Sciences Ringgold standard institution - Pathology and Medicine New Delhi India

OBJECTIVES: Cardiovascular diseases are the major cause of mortality amongst diabetic patients. This study was conducted to compare anthropometric, haematological and lipid variables in diabetic and non-diabetic Indians. The presence of coronary calcifications on the angiogram was further associated with above variables. METHODS: Prospective study in 1000-bedded hospital in North-India, comprising 105 (30 diabetic, 75 non-diabetic) patients undergoing coronary angiography. Hypertension, smoking, alcohol intake, statin >6 months, previous MI were excluded. Lipid profile, HbA1c, BMI, waist-hip ratio, complete blood count, mean platelet volume (MPV), was measured. Continuous variables were correlated using correlation coefficients, and compared between diabetes and coronary-calcification groups, using a t-test. Chi-square-test used for associating diabetes with coronary calcifications. RESULTS:Triglyceride-HDLc-ratio, Neutrophil-Lymphocyte-Ratio, WHR and MPV most significantly differed between diabetics and non-diabetics (p<0.01) and correlated well with HbA1c (p<0.001).Total cholesterol and LDLc were not significant. Patients with coronary calcifications had higher neutrophil-lymphocyte-ratio (p<0.01), as compared to TLC (p<0.05). Diabetics were more likely to have coronary calcifications (p<0.05, OR3.25 95%CI 1.184-8.920). CONCLUSION: Central obesity and dyslipidaemia contribute to chronic inflammation in diabetes with cardiac complications. Triglyceride-HDLc-ratio, Neutrophil-Lymphocyte-Ratio, and MPV are simple, inexpensive markers for dyslipidaemia and inflammation, assuming significance in low-resource settings. KEY WORDS: Angiography, Diabetes Mellitus, Dyslipidemias, Vascular Calcification

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Cite This Article

Yadav P, Mangalesh S, Dudani S. Calcified Coronary Lesions in Diabetes – Culmination of Dyslipidaemia and Inflammation. EJMO. ; (): -

Corresponding Author: Sharmila Dudani