Ahead of Print | DOI: 10.14744/ejmo.2021.16863

MiR-19a Mediates Epithelial Mesenchymal Transition of Breast Cancer by Inhibiting KRAS

Xianchou Xu¹, Peinan Wen², Yinghao Wang³, Adheesh Bhandari³, Riyuan Zhang², Shuqiang Shi², Ouchen Wang^3
1Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, China, ²Department of general Surgery, The People’s Hospital of Pingyang, Wenzhou, Zhejiang, China, ³Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China,

It has been shown that microRNAs (miRNAs) provide functions that are necessary for quantities of biological processes in cancers. Epithelial to mesenchymal transition (EMT) plays a momentous role in the progression of malignant tumor cells metastasis. However, miR-19a has not been reported to be involved in EMT of breast cancer (BC). In this study, it was investigated that miR-19a was markedly reduced in BC clinical samples and cells. Ectopic expression of miR-19a blocked BC EMT. Mechanistic analyses indicated that kirsten rat sarcoma viral oncogene homolog (KRAS) was regulated by miR-19a directly. In addition, we showed that the overexpression of KRAS greatly attenuated the anti-invasive effect induced by miR-19a. This study sheds light on miR-19a inhibits BC cell EMT and invasiveness by targeting KRAS. Therefore, miR-19a and KRAS could be served as novel targets for BC biological therapy. Keywords: BC, miR-19a, EMT, KRAS

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Cite This Article

Xu X, Wen P, Wang Y, Bhandari A, Zhang R, Shi S, et al. MiR-19a Mediates Epithelial Mesenchymal Transition of Breast Cancer by Inhibiting KRAS. EJMO. ; (): -

Corresponding Author: Ouchen Wang