A Meta-Analysis for Association of Cyclooxygenase-2 Polymorphisms with Susceptibility to Prostate Cancer
Fatemeh Asadian1, Hadi Maleki2, Sepideh Setayesh3, Seyed Alireza Dastgheib4, Mohamad Zare5, Saeed Kargar5, Seyed Hossein Shaker6, Mahta Mazaheri7, Hossein Neamatzadeh81Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran, 2Department of Urology, Alborz University of Medical Sciences, Karaj, Iran, 3Medical Student, Shiraz University of Medical Sciences, Shiraz, Iran, 4Department of Medical Genetics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, 5Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran, 6Department of Emergency Medicine, Iran University of Medical Sciences, Tehran, Iran Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran, 7Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran, 8Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran,
Objectives: A number of studies have evaluated the association of cyclooxygenase-2 (COX-2) polymorphisms with prostate cancer risk. However, the results still remain controversial. Methods: We carried out this meta-analysis to clarify the association of COX-2 polymorphisms and prostate cancer risk. An universal search in PubMed, Web of Knowledge and Google Scholar was performed to identify relevant studies up to January 2021. A total of 34 case-control studies including 11 studies with 13,248 cases and 14,768 controls were on -765G>C, 7 studies with 9,720 cases and 10,695 controls on -1195G>A, 9 studies with 11,476 cases and 11,761 controls on +202C>T, and 7 studies with 12,220 cases and 12,496 controls were on +8473T>C were selected. Results: Pooled data showed that the COX-2 +202C>T polymorphism (T vs. C: OR= 1.305, 95% CI: 1.849-9.490; p= 0.001; TT+TC vs. CC: OR= 0.781, 95% CI: 0.669-0.913; p=0.002) was associated with risk of prostate cancer, but not the -765G>C, -1195G>A and +8473T>C polymorphisms. Stratified analyses showed that the -765G>C, -1195G>A and +202C>T polymorphisms were associated with prostate cancer risk by ethnicity. Conclusion: To sum up, our results indicated that the COX-2 +202C>T polymorphism was associated with risk of prostate cancer, while the -765G>C, -1195G>A and +8473T>C polymorphisms were not associated. Keywords: Cyclooxygenase, prostate cancer, prostatic neoplasms, prostaglandin-endoperoxide synthases, polymorphism
Cite This Article
Asadian F, Maleki H, Setayesh S, Dastgheib S, Zare M, Kargar S, et al. A Meta-Analysis for Association of Cyclooxygenase-2 Polymorphisms with Susceptibility to Prostate Cancer. EJMO. 2021; 5(3): 228-238
Corresponding Author: Hadi Maleki