Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas
Semra Paydas1, Emine Kilic Bagir2, Melek Ergin2, Gulsah Seydaoglu3, Mahmut Buyuksimsek4, Asli Boz31Department of Medical Oncology, Cukurova University Faculty of Medicine, Adana, Turkey, 2Department of Pathology, Cukurova University Faculty of Medicine, Adana, Turkey, 3Department of Biostatistics, Cukurova University Faculty of Medicine, Adana, Turkey, 4Department of Medical Oncology, University of Health Sciences, Adana Health Practice and Research Center, Adana, Turkey,
Objectives: Dual specificity phosphatase 22 (DUSP22) is a novel phosphatase and has been demonstrated to be a cancer suppressor gene associated with various biological and pathological processes. The aim of this study is to evaluate the prognostic importance of DUSP22 expression in low-grade lymphomas. Methods: Fluorescence in situ hybridization (FISH) was used to detect DUSP22 and 76 cases with indolent lymphoma were evaluated for DUSP22 expression. Thirty-nine had follicular lymphoma (FL), 30 had marginal zone lymphoma (MZL) and 7 had chronic lymphocytic leukemia (CLL). Results: DUSP22 expression was detected in 17 cases (22.3%). The mean overall survival (OS) was found to be longer in cases without DUSP22 compared to cases with DUSP22 expression while event-free survival (EFS) was not different between the cases according to the DUSP22 expression. In univariate analysis, stage (early-stage disease p=0.0001), gender (female p=0.009) and DUSP22 expression (p=0.018) were found to be independent prognostic factors according to Cox regression analysis. . Conclusion: There is no sufficient data about the clinical and/or prognostic significance of DUSP22 rearrangement in lymphomas except ALK (-) anaplastic large cell lymphoma. We found that DUSP22 is poor prognostic indicator in cases with low grade lymphomas. Keywords: DUSP22, lymphoma, survival
Cite This Article
Paydas S, Kilic Bagir E, Ergin M, Seydaoglu G, Buyuksimsek M, Boz A. Prognostic Importance of DUSP22 (Dual Specificity Phosphatase 22) Gene Expression in Low-Grade Lymphomas. EJMO. 2021; 5(4): 327-331
Corresponding Author: Mahmut Buyuksimsek