Chemomodulatory Effect of Capsaicin Encapsulated Chitosan Nanoparticles on Lipids, Lipoproteins and Glycoprotein Components in DMBA Induced Mammary Carcinogenesis in Rats
Kalaiyarasi Dhamodharan1, Manobharathi Vengaimaran1, Mirunalini Sankaran11Department of Biochemistry and Biotechnology, Annamalai University, Chidambaram, Tamil Nadu, India,
Objectives: Breast cancer is a dreadful public health issue that kills plenty of women all around the world. The peril of breast cancer is strongly linked to lipids, lipoproteins, and glycoproteins. Capsaicin (CAP), a natural alkaloid isolated from chilies, has been reported to possess excellent anti-cancer activity. Unfortunately, the clinical application of this compound is strictly limited due to its low solubility and poor bioavailability. Nanoparticle-based drug delivery systems have set the path for a revolution in cancer therapy by improving its therapeutic value. The aim of the present study was to investigate the effect of CAP encapsulated chitosan nanoparticles (CAP@CS-NP) on lipids, lipoproteins and glycoproteins abnormalities in 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary carcinogenesis. Methods: A mammary tumor was induced by a single dose of DMBA 25mg/kg b.wt injected subcutaneously near the mammary gland. The levels of lipid profile, lipoproteins and glycoprotein components were analyzed in the plasma, liver and mammary tissues. Results: We observed higher levels of total cholesterol (TC), triglycerides (TG), phospholipids (PL), free fatty acids (FFA), hexose, hexosamine and sialic acid in DMBA induced tumor-bearing rats. Moreover, low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) levels were raised and high-density lipoprotein cholesterol (HDL-C) levels were dropped in tumor-bearing rats. The result shows that, CAP@CS-NP 4mg/kg b.wt administration significantly recouped abnormal levels to near-normal levels. It was additionally verified by histological staining in mammary tissues. Conclusion: Our findings suggest that nanoencapsulation of CAP@CS-NP successfully regulates lipid profile, lipoproteins, and glycoproteins levels. Keywords: Breast cancer, Capsaicin, Nanoparticle, Glycoproteins, Lipids
Cite This Article
Dhamodharan K, Vengaimaran M, Sankaran M. Chemomodulatory Effect of Capsaicin Encapsulated Chitosan Nanoparticles on Lipids, Lipoproteins and Glycoprotein Components in DMBA Induced Mammary Carcinogenesis in Rats. EJMO. 2021; 5(4): 350-357
Corresponding Author: Mirunalini Sankaran