Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance
Zhichao Fu1, Li Guo1, Nanbao Zhong1, Fengmei Wang21Department of Radiotherapy, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, 350025, Fujian, China, 2Department of Obstetrics and Gynecology, 900th Hospital of Joint Logistics Support Force (Dongfang Hospital),Xiamen University, Fuzhou, Fujian, PR., China,
Objectives: The aim of this study is to investigate the prognostic impact of CXCL12 and CD44v5 on patients with advanced cervical cancer. Methods: Paraffin specimens from 130 advanced cervix cancer before radiotherapy were examined using immunohistochemistry to test the expressions of CXCL12 and CD44v5. The correlations between the expressions of CXCL12 and CD44v5 and the five-year survival rate were analyzed. The expression changes of CXCL12 and CD44v5 in residual cancer tissues after a total radiotherapy dose of 50 Gy were tested by Real-Time PCR. Results: In the 130 patients, a significant correlation was found between CXCL12 and CD44v5 (P=0.028). The coexpression occurred in 34 patients with lower five-year survival rate of 22.9%.There was no correlation between the expression of CXCL12 and CD44v5 and age, tumor stage, size, pelvic lymph node involvement and therapeutic schedule. Log-rank and multi-factor survivals analysis showed that tumor stage, lymph node involvement, CXCL12 expression, CD44v5 expression, CXCL12 and CD44v5 co-expression were independent prognostic factors. The expressions of CXCL12 and CD44 were significant elevated in residual tumor tissues, when compared to pre-radiotherapy, (p<0.05). Conclusion: A significant positive correlation occurred between the expression of CXCL12 and CD44v5. The coexpression might be informative regarding poor prognosis in patients with radical radiotherapy. Keywords: Cervical cancer, coexpression, CXCL12, CD44v5, prognosis, radiotherapy
Cite This Article
Fu Z, Guo L, Zhong N, Wang F. Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance. EJMO. 2023; 7(2): 189-196
Corresponding Author: Nanbao Zhong